NAD+
Proper Handling
- Reconstitute with Bacteriostatic Water
- Specifications: Lyophilized powder in 10 mL vial. Purity (>99%) meets or exceeds U.S. Pharmacopeia (USP) regulations.
- Storage: In lyophilized form, the peptide is stable for 3 years. Protect from light. Refrigerate and use within 4-6 weeks after opening or reconstituting.
NAD+ (Nicotinamide Adenine Dinucleotide) is a crucial coenzyme found in every living cell that plays a central role in numerous biological processes, including cellular energy production, DNA repair, gene expression, and cellular defense mechanisms. NAD+ acts as a key molecule in redox reactions, facilitating the transfer of electrons and promoting the conversion of nutrients into energy (ATP) through metabolic pathways like glycolysis, the Krebs cycle, and oxidative phosphorylation.
As people age, levels of NAD+ in the body naturally decline. This decrease in NAD+ is associated with several age-related health issues, including reduced energy production, impaired DNA repair, increased oxidative stress, and metabolic disorders. Restoration of NAD+ levels has been shown to promote better health in aging individuals by improving energy metabolism, DNA repair, and cellular resilience. Increasing NAD+ levels is also thought to activate sirtuins, which enhance mitochondrial function and extend healthy lifespan.
Science-Backed Research
- Supports cellular energy production
- Enhances mitochondrial function
- Promotes healthy aging
- Boosts DNA repair
- Improves cognitive function
- Supports metabolic health
- Enhances muscle function and recovery
CAS Number 53-84-9
Molecular Weight 663.4 g/mol-1
Molecular Formula C21H27N7O14P2
Synonyms Nadide; 53-84-9; coenzyme I; beta-NAD
This product is sold as a pure compound for research purposes only, unless prescribed by a licensed physician. This product comes in the form of lyophilized powder and must be reconstituted with bacteriostatic water prior to use. Please refer to our terms and conditions prior to purchase.
Safety Information: Keep this product out of the reach of children. This material has limited research available about it and may result in adverse effects if improperly handled or consumed. This product is not a dietary supplement, but a pure substance, sold as a raw material. We attest exclusively to the quality, purity and description of the materials we provide. This product is for use and handling only by persons with the knowledge and equipment to safely handle this material. You agree to indemnify us for any adverse effects that may arise from improper handling and/or consumption of this product.
The articles and information on products that may be found on this website are provided exclusively for the purposes of providing information and education. These items are not pharmaceuticals or medications, and the Food and Drug Administration has not given permission for the treatment or prevention of any disease, medical condition, or ailment using them.
https://www.sciencedirect.com/science/article/abs/pii/S0962892414000634
https://www.nature.com/articles/s41580-020-00313-x
https://www.sciencedirect.com/science/article/abs/pii/S0968000406003239
https://article.imrpress.com/bri/Landmark/articles/pdf/Landmark2038.pdf
https://www.sciencedirect.com/science/article/pii/S0092867407009737
https://www.sciencedirect.com/science/article/pii/S1550413112001921
Frequently Asked Questions
NAD+
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NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in all living cells. It is critical for many biological processes, particularly those related to cellular energy production and metabolism. NAD+ exists in two forms: oxidized NAD+ and reduced NADH.
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NAD+ (nicotinamide adenine dinucleotide) has a yellow color due to its molecular structure and the way it absorbs and interacts with light. Specifically, the yellow appearance of NAD+ solutions is primarily because of the adenine ring, a component of the NAD+ molecule, which absorbs light in the ultraviolet (UV) region. This absorption can sometimes shift into the visible light spectrum, giving NAD+ a yellowish hue.
Additionally, NAD+ in its oxidized form tends to have a pale yellow color. The yellow coloration is typically more noticeable in concentrated solutions and less so in diluted preparations. The intensity of the yellow can also change based on the chemical environment or pH of the solution in which NAD+ is dissolved.
This coloration doesn't impact its efficacy or use, but it is a characteristic feature of the molecule in its oxidized form.
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NAD+ is involved in numerous biological processes, particularly energy metabolism, redox reactions, and cellular repair mechanisms.
Energy Metabolism (ATP Production):
NAD+ is a coenzyme in cellular respiration, specifically in glycolysis, the Krebs cycle, and oxidative phosphorylation. It acts as an electron transporter, accepting electrons from glucose and transferring them to the mitochondrial electron transport chain, which drives the production of ATP, the cell’s main energy source.
During these processes, NAD+ is reduced to NADH, and when NADH donates its electrons to the electron transport chain, it is oxidized back to NAD+.
DNA Repair:
NAD+ activates enzymes like poly(ADP-ribose) polymerases (PARPs), which are involved in DNA repair. By promoting the repair of damaged DNA, NAD+ helps maintain genomic stability, a key factor in preventing age-related diseases and maintaining healthy cellular function.
Sirtuin Activation:
Sirtuins are NAD+-dependent proteins that regulate critical processes like inflammation, stress resistance, energy efficiency, and longevity. NAD+ is required for sirtuin activity, which contributes to cellular repair, mitochondrial function, and aging.
Sirtuins also regulate metabolic pathways, ensuring cells adapt properly to changes in energy availability.
Regulation of Oxidative Stress:
NAD+ plays a crucial role in the body's antioxidant defense system by supporting the activity of enzymes that reduce oxidative stress and protect cells from free radical damage. This is key in aging and chronic diseases like neurodegenerative disorders and cardiovascular conditions.
Neuroprotection:
NAD+ is essential for maintaining proper neuronal function and neuroplasticity. By supporting mitochondrial health and reducing oxidative stress, it has potential neuroprotective effects, making it valuable in conditions like Alzheimer's, Parkinson's, and other neurodegenerative diseases.
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Energy Production: NAD+ plays a crucial role in the process of cellular respiration and energy production. It helps convert nutrients into ATP, the main energy currency in cells.
DNA Repair: NAD+ is vital for the repair of damaged DNA, helping maintain genomic integrity, which is crucial for longevity and preventing age-related diseases.
Sirtuin Activation: NAD+ is a key activator of sirtuins, a family of proteins that regulate cellular health, metabolism, aging, and longevity.
Cellular Detoxification: NAD+ is involved in the detoxification processes that reduce oxidative stress, which is a major contributor to aging and chronic diseases.
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Clinical Applications
NAD+ has a wide range of therapeutic applications due to its critical role in cellular metabolism, energy production, and repair processes.
Anti-Aging and Longevity:
NAD+ levels decline with age, and supplementation is believed to slow the aging process by enhancing DNA repair, improving mitochondrial function, and promoting cell survival. Studies suggest that restoring NAD+ levels can help:
- Combat age-related metabolic decline
- Improve skin elasticity and cellular repair
- Enhance cognitive function and reduce age-related neurodegeneration
Neurodegenerative Diseases:
NAD+ has potential benefits in treating neurodegenerative conditions such as Alzheimer’s disease, Parkinson’s disease, and Multiple Sclerosis. By improving mitochondrial function and reducing oxidative stress, NAD+ may slow disease progression and improve cognitive and motor function.
Substance Abuse and Addiction Recovery:
NAD+ IV therapy has been used in addiction recovery, particularly in detoxification from drugs and alcohol. NAD+ helps restore neurotransmitter balance, reduce withdrawal symptoms, and improve mental clarity, making it a valuable adjunct in addiction treatment protocols.
Chronic Fatigue Syndrome (CFS):
NAD+ has been studied as a treatment for chronic fatigue syndrome (CFS), helping improve energy levels and reduce fatigue by enhancing mitochondrial function and cellular energy production.
Cardiovascular Health:
NAD+ is crucial for maintaining heart health. Studies suggest that it helps regulate blood pressure, improve vascular elasticity, and protect against cardiovascular disease by enhancing mitochondrial function and reducing oxidative damage to blood vessels.
Metabolic Disorders:
NAD+ therapy is being investigated for its role in diabetes, obesity, and metabolic syndrome. By improving insulin sensitivity and promoting efficient energy use, NAD+ can help regulate blood sugar levels and improve metabolic health.
Immune Function:
NAD+ is important for optimal immune function, helping the body respond to infections and inflammation. It has been studied in the context of autoimmune diseases and as a supportive therapy for chronic infections like Lyme disease.
Cognitive and Mental Health:
NAD+ supports cognitive function, memory, and mental clarity. It may improve symptoms of depression, anxiety, and PTSD by balancing neurotransmitters and promoting neural health.
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Pregnancy and Breastfeeding:
There is limited research on the safety of NAD+ in pregnant or breastfeeding women, so its use is generally contraindicated in these populations unless supervised by a healthcare provider.
Active Cancer:
While NAD+ is involved in cellular repair and energy production, patients with active cancer should use it with caution. NAD+ may theoretically stimulate both normal and cancerous cells. Consultation with an oncologist is recommended before use.
Severe Allergic Reactions:
Any known hypersensitivity or allergy to NAD+ or its components is a contraindication for use.
Hypotension:
NAD+ can cause fluctuations in blood pressure, particularly during IV administration. Patients with low blood pressure (hypotension) should be closely monitored.
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- Itching or discomfort at the site of injection
- Fatigue or Mild Headache: As with IV NAD+ therapy, some patients report feeling fatigued or experiencing mild headaches following subcutaneous NAD+ injections. These side effects are usually short-lived and tend to improve with rest or hydration.
- Muscle Aches or Cramps: Some individuals experience mild muscle aches or cramps after SubQ NAD+ injections. This may be due to the effect of NAD+ on muscle function and energy metabolism. These symptoms are generally mild and resolve on their own.
- Flushing or Warm Sensation: Though more common in IV therapy, a warm or flushing sensation can occasionally occur after SubQ NAD+ injections. This is usually temporary and fades quickly.
Less Common Side Effects:
- Nausea: While less common with subcutaneous injections than with IV infusions, nausea can still occur, especially if larger doses of NAD+ are administered.
- Hypotension (Low Blood Pressure): In rare cases, NAD+ can cause a slight drop in blood pressure, potentially leading to light-headedness or faintness
- Muscle Tightness or Spasms: Some individuals may report muscle tightness or spasms after NAD+ SubQ injections, particularly if the injection site is near a muscle or if the dose was higher than usual.
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IV Therapy: Intravenous NAD+ administration is preferred for acute conditions and when higher doses are needed to rapidly raise NAD+ levels.
Subcutaneous Injection: In some protocols, NAD+ can be administered via subcutaneous injections, though this method is less common than IV therapy for acute conditions.
Oral Precursors: Oral NAD+ supplements or its precursors (NR and NMN) are more convenient for long-term use but may not deliver the immediate effects seen with IV or subcutaneous administration.
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We're happy to help answer questions you may have, or refer you to a licensed healthcare professional for medical advice. Email us at care@somapeptides.com or schedule a consult.