Retatrutide

$169.00
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Proper Handling
  • Reconstitute with Bacteriostatic Water
  • Specifications: Lyophilized powder in 3 mL vial. Purity (>99%) meets or exceeds U.S. Pharmacopeia (USP) regulations.
  • Storage: In lyophilized form, the peptide is stable for 3 years. Protect from light. Refrigerate and use within 4-6 weeks after opening or reconstituting.
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Retatrutide is an investigational treatment for obesity that is a triple hormone receptor agonist. Retatrutide is a gastric inhibitory polypeptide (GIP), glucagon-like peptide-1 (GLP-1) and glucagon receptor agonist.

Retatrutide works in the treatment of obesity by targeting three different hunger regulating hormones:

  • GIP (gastric inhibitory peptide or glucose-dependent insulinotropic polypeptide) is an incretin hormone that is released from the gut after eating. It stimulates the beta-cells in the pancreas to secrete insulin.
  • GLP-1 (glucagon-like peptide-1) is also an incretin hormone that stimulates the beta-cells to secrete insulin.
  • Glucagon is a hormone secreted from the alpha-cells in the pancreas. It stimulates glucose production in the liver and helps maintain adequate plasma glucose concentrations.

The drug has been nicknamed 'triple G' because it is an agonist of all three receptors.

CAS Number 2381089-83-2

PubChem CID 474492335

Molecular Weight 4845.44 g/mol

Molecular Formula C223H343F3N46O70

Synonyms LY-3437943, NOP2Y096GV

GCGR agonists(Glucagon receptor agonists),GIPR agonists(Gastric inhibitory polypeptide receptor agonists),GLP-1R agonists(Glucagon-like peptide 1 receptor agonists)

Storage (Lyophilized) At 39 Fahrenheit: 2 years
At -4 Fahrenheit: 3 years

  1. Rosenstock J, Frias J, Jastreboff AM, et al. Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial conducted in the USA. Lancet. 2023;402(10401):529-544. doi: 10.1016/S0140-6736(23)01053-X
  2. Urva S, O’Farrell L, Du Y, et al. The novel GIP, GLP-1 and glucagon receptor agonist retatrutide delays gastric emptying. Diabetes Obes Metab. 2023;25(9):2784-2788. doi: 10.1111/dom.15167
  3. Sinha B, Ghosal S, Mukhopadhyay S, et al. Glucagon-related advancements in diabetes therapy. J Diabetol. 2023;14:S16-S18. doi: 10.4103/jod.jod_96_23

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Retatrutide

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Speak with licensed physicians and specialists in peptide therapy about proper dosage, reconstituting lyophilized peptides, titrating up (or down), and proper care and consideration of your medical history.